Medical Instructor & Trainer

  • 1985–
    German Medical Students (over 20) who have been sent to me as part of the German Neuroscience Fund for Research (Dichtgangs) and have since entered German Neuroscience
    Trainer. One student per year for 2–4 months.
    Effort spent: 40 hrs/yr

Formal Teaching of Residents, Clinical Fellows, and Research Fellows (post–docs)

Harvard Medical School

  • 1978–
    15 Fellows
    200 hrs/year
  • 1978–
    Fellowship Mentor
    1 Fellow
    1 Fellow/year
  • 2012–
    Post-doc and pre-doc mentor with Xandra Breakefield of Dr. Leonora Balaj (BEAMing studies of eoxomal mutations in biofluids), Nadia Atai (exosomal isolation from vitreal and plasma fluids) and Ms. Qui with Drs. Langer and Cima (MIT)(novel delivery system for intracerebral steroids).

Clinical, Supervisory and Training Responsibilities

Massachusetts General Hospital

  • 1978–1990
    Neurology Attending Physician
    1 month/year
  • 1980–
    Since entering Neuroscience: mentor to visiting German Neuro-Oncology students sent to me as part of the German Neuroscience Fund for Research (Dichgans)
    80 hours/year
  • 1990–
    Neurology Attending Physician
    1 month/year
  • 1998–
    Clinical Neuro-Oncology Fellow
    3 years under NIH Fellowship Program
  • 2009– present
    Student teaching: I have had college and medical student observers, for 2–8 months, involved in projects including Waldenstrom’s neurologic involvement, exosomal isolation from vitreal fluids, exosomal isolation after orthopedic surgery. These continue, two per year, to the present.

Formally Supervised Trainees

  • 1975: N. Kopp
    Neuropathologist, Centre of Anato Pathologie,
    Hospital Neurologique, Lyon FR
    Published with me on the syndrome of Admakiewicz
  • 1985: Beth Henriksen
    Neurologist and Director, Rehabilitation Hospital (Karolinska Affiliate), Stockholm, Sweden
    Published with me on pain syndromes associated with prostate cancer.
  • 1986–1987: Rifaat Bashir
    Clinical Clerkship Director, Neurology, Drexel University, Harrisburg, PA
    Published with me on EBV – associated brain lymphoma and molecular markers of EBV infection
  • 1989–1991: Michael Gruber
    Clinical Professor Neurosurgery (Neuro-Oncology), New York University, New York, NY
    Publications with me of Methotrexate therapy of Primary Brain Lymphoma
  • 1990: Jon Glass
    Associate Professor Neurology (Neuro-Oncology),
    Thomas Jefferson University Hospitals, Philadelphia, PA
    Published with me on outcome of therapy of lymphoma, MRI blood volume measures of brain tumor growth and M-CHOD therapy of brain lymphoma
  • 1990: Rohit Bakshi
    Associate Professor, Neurology (Multiple Sclerosis and Imaging) Harvard Medical School, Boston, MA
    Published with me on leukoencephalitic masses of brain and brain tumors in eye doctors
  • 1992–1993: Lawrence Cher
    Attending Neurologist (Neuro-Oncology), Austin Hospital, Melbourne, Australia
    Published with me an outcome of therapy of lymphoma
  • 1993: Raul Valenzuela
    Associate Professor of Neurology (Neuro-Oncology) Catholic University of Chile, Santiago, Chile
    Publications with me on Protein A therapy of paraneoplastic syndromes, and In Situ X-ray therapy of glioblastoma. Studies published with me of chronic Manganism in Chilean miners.
  • 1995: Asha Das
    Neuro-Oncologist, Cedars-Sinai Medical Center (Los Angeles) and National Neurosciences Center (Singapore)
    Publications with me on the therapy of paraneoplastic syndromes.
  • 1995: Lyndon Kim
    Neuro-Oncologist, Neuro-Oncology Branch (H. Fine), NIH, Bethesda, MD
    Publications with me on PCV Therapy of Oligodendrogliomas
  • 1996: Denise Damek
    Associate Professor of Neurology (Neuro-Oncology),
    University of Colorado Medical Center, Boulder, CO
    Publications with me on Nerve Seeking Lymphoma (Neurolymphomatosis)
  • 1996: Wolfgang Wick
    Professor Neuro-Oncology, University of Heidelberg, Germany
    Published with me on parkinsonism after brain irradiation for brain tumors.
  • 1997–1999
    Amy A. Pruitt, Associate Professor of Neurology,
    University of Pennsylvania, Philadelphia, PA
    Academic Neuro-Oncologist co-authored definitive paper on recurrence patterns in glioblastoma that set the stage for localized therapy of this tumor. Co-authored paper on arterial chemotherapy of this tumor.
  • 1997–1999: Roy Meckler
    Clinical Neurologist, Louisville, KY
    Research with me on EBviral-associated neurologic diseases while I was Chief Resident in Neuro-Pathology at MGH, Boston, MA
  • 2002–2003: Joachim Baehring
    Associate Professor of Neurology and Neurosurgery,
    Chief, Neuro-Oncology, Yale University Medical Center, New Haven, CT
    Publications with me on molecular features of brain lymphoma, primary brain lymphoma, intravascular lymphoma, and immunoglobulin gene rearrangement of B cells in brain lymphoma.
  • 2003–2005: Suriya Jeyapalan
    Assistant Professor of Neurology (Neuro-Oncology),
    Beth Israel Deaconess Medical Center, Boston, MA
    Designed with me the study of ALIMTA therapy of brain lymphoma and herpes gene therapy of glioblastoma.
  • 2004–2005: Jan Drappatz
    Neuro-Oncologist, Harvard Medical School, Boston, MA
    Instructor in Medicine, Dana-Farber Cancer Institute, Boston, MA
  • 2006–2007: Andrew Norden
    Neuro-Oncologist, Harvard Medical School, Boston, MA
    Instructor in Medicine, Dana-Farber Cancer Institute, Boston, MA
  • 2007–2009: Andrew Chi
    Neuro-Oncologist, Harvard Medical School, Boston, MA
    Instructor in Medicine, Massachusetts General Hospital, Boston, MA
  • 2007–2009: Milan Chheda
    Neuro-Oncologist, Memorial Sloane Kettering
    Instructor in Medicine, Massachusetts General Hospital, Boston, MA
  • 2007–2008: Bryan Scott
    Lahey Clinic, Burlington, MA
  • 2009– : Andreas Rimner
    Radiation Therapist
    Memorial Sloane Kettering
  • 2012– : Leonora Balaj
    Mass. General Hospital (Neurogenetics PhD)
    Post-doctoral student, Breakefield Lab Molecular Genetics
  • 2012–2014: Qunya Ong
    MIT (Molecular Chemistry Ph.D.)
    Post-doctoral studies A Star Singapore
  • 2012–2015: Nadia Atai
    University of Amsterdam (MD, PHD)
    Post-doctoral studies Amsterdam
  • 2014: Huilin Shao
    Harvard and A Star (Singapore PhD)
    Post-doctoral studies, A Star

Formal Teaching of Peers

CME and Other Continuing Education

  • 1976–
    Multi-disciplinary Neuro-oncology Case Conference attended by staff of Radiation therapy, Neuro-Radiology, Neurosurgery, Oncology, Neuro-Oncology and Nursing at the Massachusetts General Hospital.
    Two hours per week
    Case Conference
    Boston, MA
    Massachusetts General Hospital
  • 1976–
    Presented at the Harvard Neurology and Brain Tumor post-graduate classes.
    12-14 hours per year
    Post-Graduate Course
    Boston, MA
    Harvard Medical School,
    Boston, MA
  • 1978–
    Neurology, Cancer of the Nervous System
    2 lectures/course
    Post-Graduate Course
    Boston, MA
    Harvard Medical School
  • 1980–2005
    Case-based presentations in Neuro-Oncology. These discussions, which I chair, are attended by resident Neurology staff and Neuro-Oncology nurses and fellows.
    Four hours per week
    Didactic Conference
    Boston, MA
    Massachusetts General Hospital
  • 2002–
    I created the Carolyn-Frye Halloran conferences to provide brain tumor translational research activities to colleagues and the lay public. These conferences are held before audiences of 25–300 people and have included topics primed for translation to patients. Topics have included:
    1. Microdialysis to measure chemotherapeutic materials in human brain tumors.
    2. Brain lymphoma.
    3. Stem cells and brain tumors.
    4. Racial disparities in brain tumors.
    5. Immunization strategies in brain tumors.
    6. Gene therapy of brain tumors.
    7. Molecular markers of metastases to brain.
    8. Neuroectodermal syndromes as models of brain tumor development.
    9. Biomarkers of glioma
    10. Exosomes and the nervous system
    Thirty hours per year
    Didactic Conference
    Boston, MA
    Massachusetts General Hospital